NO. NO NO NO NO NO NO NO NO NO. Lissanna is hardly seen with Natsu anymore and she is a wimp. Loke is hardly seen with LUCY, only in battle. Plus, Loke is a SPIRIT!! So dats impossible. NALU is the only possible outcome. Pluss, they are both main characters. They have been in EVERY SINGLE EPISODE SINCE THE BEGGINING OF TIME ITS SELF.
LoLu and NaLi are in the trash where they should be! ^.^ (P.s. This commenter is a HUGEEEEEE NALU fan. Disagree with her, and you with find your account hacked.)